Positive patient experiences and improvement of vagal cardiac control due to Kava treatment were also reported in the literature. Kava is an appealing treatment option to GAD patients who are more attune to natural remedies or lifestyle approaches to reduce stress. Meta-analyses of the results of three placebo-controlled trials (n = 130) favored Kava for GAD treatment with effect sizes between 0.59 and 0.99 (standard mean difference) without reaching statistical significance. One negative trial demonstrated that Kava was not more effective than placebo. Evidence supporting Kava as an effective treatment for GAD was found in two placebo-controlled trials and a reference-controlled trial. Twelve articles were included in this review. Systematic search of English-language publications from major databases for clinical trials reporting the effects of Kava for the treatment of GAD. To perform a systematic review and meta-analysis of the available evidence on Kava as a treatment for GAD. Kava (Piper methysticum) has been explored as a potential phytotherapeutic option for GAD. Treatment of GAD with antidepressants and benzodiazepines is only moderately effective and not free from side effects. Generalized anxiety disorder (GAD) is a chronic and debilitating condition characterized by persistent and overpowering anxiety.
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